Human subcortical pathways automatically detect collision trajectory without attention and awareness.

Detecting imminent collisions is essential for survival. Here, we used high-resolution fMRI at 7 Tesla to investigate the role of attention and consciousness for detecting collision trajectory in human subcortical pathways. Healthy participants can precisely discriminate collision from near-miss trajectory of an approaching object, with pupil size change reflecting collision sensitivity. Subcortical pathways from the superior colliculus (SC) to the ventromedial pulvinar (vmPul) and ventral tegmental area (VTA) exhibited collision-sensitive responses even when participants were not paying attention to the looming stimuli. For hemianopic patients with unilateral lesions of the geniculostriate pathway, the ipsilesional SC and VTA showed significant activation to collision stimuli in their scotoma. Furthermore, stronger SC responses predicted better behavioral performance in collision detection even in the absence of awareness. Therefore, human tectofugal pathways could automatically detect collision trajectories without the observers' attention to and awareness of looming stimuli, supporting "blindsight" detection of impending visual threats.

Robust functional mapping of layer-selective responses in human lateral geniculate nucleus with high-resolution 7T fMRI.

The lateral geniculate nucleus (LGN) of the thalamus is the major subcortical relay of retinal input to the visual cortex. It plays important roles in visual perception and cognition and is closely related with several eye diseases and brain disorders. Primate LGNs mainly consist of six layers of monocular neurons with distinct cell types and functions. The non-invasive measure of layer-selective activities of the human LGN would have broad scientific and clinical implications. Using high-resolution functional magnetic resonance imaging (fMRI) at 7 Tesla (T) and carefully designed visual stimuli, we achieved robust functional mapping of eye-specific and also magnocellular/parvocellular-specific laminar patterns of the human LGN. These laminar patterns were highly reproducible with different pulse sequences scanned on separate days, between different subjects, and were in remarkable consistency with the simulation from high-resolution histology of the human LGNs. These findings clearly demonstrate that 7T fMRI can robustly resolve layer-specific responses of the human LGN. This paves the way for future investigation of the critical roles of the LGN in human visual perception and cognition, as well as the neural mechanisms of many developmental and neurodegenerative diseases.

Binocular rivalry from invisible patterns.

Binocular rivalry arises when incompatible images are presented to the two eyes. If the two eyes' conflicting features are invisible, leading to identical perceptual interpretations, does rivalry competition still occur? Here we investigated whether binocular rivalry can be induced from conflicting but invisible spatial patterns. A chromatic grating counterphase flickering at 30 Hz appeared uniform, but produced significant tilt aftereffect and orientation-selective adaptation. The invisible pattern also generated significant BOLD activities in the early visual cortex, with minimal response in the parietal and frontal cortical areas. Compared with perceptually matched uniform stimuli, a monocularly presented invisible chromatic grating enhanced the rivalry competition with a low-contrast visible grating presented to the other eye. Furthermore, switching from a uniform field to a perceptually matched invisible chromatic grating produced interocular suppression at approximately 200 ms after onset of the invisible grating. Experiments using briefly presented monocular probes revealed evidence for sustained rivalry competition between two invisible gratings during continuous dichoptic presentations. These findings indicate that even without visible interocular conflict, and with minimal engagement of frontoparietal cortex and consciousness related top-down feedback, perceptually identical patterns with invisible conflict features produce rivalry competition in the early visual cortex.